CX3CL1/fractalkine shedding by human hepatic stellate cells: contribution to chronic inflammation in the liver.

Archive ouverte | Bourd-Boittin, Katia | CCSD

International audience. Chemokines are the inflammatory mediators that modulate liver fibrosis, a common feature of chronic inflammatory liver diseases. CX3CL1/fractalkine is a membrane-associated chemokine that req...

Protease profiling of liver fibrosis reveals the adam metallopeptidase with thrombospondin type 1 motif, 1 as a central activator of TGF-β

Archive ouverte | Bourd-Boittin, Katia | CCSD

International audience. During chronic liver disease, tissue remodeling leads to dramatic changes and accumulation of matrix components. Matrix metalloproteases and their inhibitors have been involved in the regulat...

MMP2 contributes to CX3CL1 shedding in hepatic stellate cells during liver injury

Archive ouverte | Bourd-Boitin, K. | CCSD