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Selective suppression of hippocampal ripples impairs spatial memory.

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Girardeau, Gabrielle | Benchenane, Karim | Wiener, Sidney, I. | Buzsáki, György | Zugaro, Michaël

Edité par CCSD ; Nature Publishing Group -

International audience. Sharp wave-ripple (SPW-R) complexes in the hippocampus-entorhinal cortex are believed to be important for transferring labile memories from the hippocampus to the neocortex for long-term storage. We found that selective elimination of SPW-Rs during post-training consolidation periods resulted in performance impairment in rats trained on a hippocampus-dependent spatial memory task. Our results provide evidence for a prominent role of hippocampal SPW-Rs in memory consolidation.

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