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Clustering patterns of LOD scores for asthma-related phenotypes revealed by a genome-wide screen in 295 French EGEA families.

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Bouzigon, Emmanuelle | Dizier, Marie-Hélène | Krähenbühl, Christine | Lemainque, Arnaud | Annesi-Maesano, Isabella | Betard, Christine | Bousquet, Jean | Charpin, Denis | Gormand, Frédéric | Guilloud-Bataille, Michel | Just, Jocelyne | Le Moual, Nicole | Maccario, Jean | Matran, Régis | Neukirch, Françoise | Oryszczyn, Marie-Pierre | Paty, Evelyne | Pin, Isabelle | Rosenberg-Bourgin, Myriam | Vervloet, Daniel | Kauffmann, Francine | Lathrop, Mark | Demenais, Florence

Edité par CCSD ; Oxford University Press (OUP) -

International audience. A genome-wide scan for asthma phenotypes was conducted in the whole sample of 295 EGEA families selected through at least one asthmatic subject. In addition to asthma, seven phenotypes involved in the main asthma physiopathological pathways were considered: SPT (positive skin prick test response to at least one of 11 allergens), SPTQ score being the number of positive skin test responses to 11 allergens, Phadiatop (positive specific IgE response to a mixture of allergens), total IgE levels, eosinophils, bronchial responsiveness (BR) to methacholine challenge and %predicted FEV(1). Four regions showed evidence for linkage (P

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