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TNF in host resistance to tuberculosis infection.

Archive ouverte | Quesniaux, Valérie | CCSD

International audience. TNF is essential to control Mycobacterium tuberculosis infection and cannot be replaced by other proinflammatory cytokines. Overproduction of TNF may cause immunopathology, while defective TN...

Limited role for lymphotoxin α in the host immune response to Mycobacterium tuberculosis.

Archive ouverte | Allie, Nasiema | CCSD

International audience. The contribution of lymphotoxin (LT)α in the host immune response to virulent Mycobacterium tuberculosis and Mycobacterium bovis bacillus Calmette-Guérin infections was investigated. Despite ...

Dominant-negative tumor necrosis factor protects from Mycobacterium bovis Bacillus Calmette Guérin (BCG) and endotoxin-induced liver injury without compromising host immunity to BCG and Mycobacterium tuberculosis.

Archive ouverte | Olleros, Maria L | CCSD

International audience. BACKGROUND: Tumor necrosis factor (TNF) is associated with the development of inflammatory pathologies. Antibodies and soluble TNF (solTNF) receptors that neutralize excessive TNF are effecti...

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