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Influence of inoculum size on the selection of resistant mutants of Escherichia coli in relation to mutant prevention concentrations of marbofloxacin.

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Ferran, Aude | Dupouy-Guiraute, Véronique | Toutain, Pierre-Louis | Bousquet‐mélou, Alain

Edité par CCSD ; American Society for Microbiology -

International audience. We demonstrate using an in vitro pharmacodynamic model that the likelihood of selection of Escherichia coli mutants resistant to a fluoroquinolone was increased when the initial size of the bacterial population, exposed to fluoroquinolone concentrations within the mutant selection window, was increased.

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