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Receptor kinase profiles identify a rationale for multitarget kinase inhibition in immature T-ALL.

Archive ouverte | Lhermitte, L. | CCSD

International audience. Constitutively activated FLT3 signaling is common in acute myeloid leukemia, and is currently under evaluation for targeted therapy, whereas little data is available in T-cell acute lymphobla...

Extensive molecular mapping of TCR / - and TCR -involved chromosomal translocations reveals distinct mechanisms of oncogene activation in T-ALL

Archive ouverte | Le Noir, S. | CCSD

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Age-related clinical and biological features of PTEN abnormalities in T-cell acute lymphoblastic leukaemia

Archive ouverte | Tesio, M | CCSD

International audience. The tumour suppressor gene PTEN is commonly altered in T-cell acute lymphoblastic leukaemia but its prognostic impact is still debated. We screened a cohort of 573 fully characterised adult a...

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