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Magnetic Multilamellar Liposomes Produced by In Situ Synthesis of Iron Oxide Nanoparticles: "Magnetonions"

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Faure, Chrystel | Meyre, Marie-Edith | Trépout, Sylvain | Lambert, Olivier | Lebraud, Eric

Edité par CCSD ; American Chemical Society -

8 pages. International audience. We report the formation of magnetic onion-type multilamellar vesicles. Iron oxide nanoparticles (np's) were synthesized inside lipidic multilamellar vesicles by coprecipitation of vesicle-encapsulated Fe2+ and Fe3+ ions induced by HO- diffusion through vesicle lamellae. The iron ion encapsulation efficiency of onions was measured by potentiometry and UV-vis absorbance spectroscopy. Its high value (75 ( 5% for both Fe2+ and Fe3+) ensures an intravesicular synthesis, as confirmed by cryo-transmission electron microscopy (TEM) imaging. The as-grown nanoparticles are characterized by X-ray diffraction analysis and TEM, and magnetic onions are imaged by cryo-TEM. The np size, controlled by temperature and time, ranges from 3 to 6 nm and is shown to be a key parameter for onion stability.

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