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Novel powerful water-soluble lipid immunoadjuvants inducing mouse dendritic cell maturation and B cell proliferation using TLR2 pathway.

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Spanedda, Maria Vittoria | Heurtault, Béatrice | Weidner, Steffen | Baehr, Corinne | Boeglin, Emmanuelle | Beyrath, Julien | Milosevic, Sara | Bourel-Bonnet, Line | Fournel, Sylvie | Frisch, Benoît

Edité par CCSD ; Elsevier -

International audience. Four novel water-soluble lipid immunoadjuvants were designed, synthesized and characterized by MS and NMR. They all induce mouse dendritic cell maturation and B cell proliferation. We demonstrate that in spite of the chemical modification, the four compounds remain TLR2 agonists.

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