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Efficient delivery of angiostatin K1-5 into tumors following insertion of an NGR peptide into adenovirus capsid.

Archive ouverte | Jullienne, B. | CCSD

International audience. Adenovirus (Ad)-mediated delivery of anti-angiogenic molecules into tumors constitutes an appealing approach for growth inhibition. However, lack of expression on tumors of Ad receptors leads...

Persistent STAT5 activation in myeloid neoplasms recruits p53 into gene regulation

Archive ouverte | Girardot, M. | CCSD

International audience. STAT (Signal Transducer and Activator of Transcription) transcription factors are constitutively activated in most hematopoietic cancers. We previously identified a target gene, LPP/miR-28 (L...

Germline duplication of ATG2B and GSKIP predisposes to familial myeloid malignancies

Archive ouverte | Saliba, J. | CCSD

International audience. No major predisposition gene for familial myeloproliferative neoplasms (MPN) has been identified. Here we demonstrate that the autosomal dominant transmission of a 700-kb duplication in four ...

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