Well-differentiated and dedifferentiated liposarcomas.

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Well-differentiated and dedifferentiated liposarcomas.

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Coindre, Jean-Michel | Pédeutour, Florence | Aurias, Alain

Edité par CCSD ; Elsevier (Cell Press) -

International audience. Atypical lipomatous tumor or well-differentiated liposarcoma (ALT-WDLPS) and dedifferentiated liposarcoma (DDLPS) share the same basic genetic abnormality characterized by a simple genomic profile with a 12q14-15 amplification involving MDM2 gene. These tumors are the most frequent LPS. This paper reviews the molecular pathology, general clinical and imaging features, histopathology, new diagnostic tools, and prognosis of ALT-WDLPS and DDLPS.

Langue: en

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