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Evidence for crucial electrostatic interactions between Bcl-2 homology domains BH3 and BH4 in the anti-apoptotic Nr-13 protein.

Archive ouverte | Lalle, P. | CCSD

International audience. Nr-13 is an anti-apoptotic member of the Bcl-2 family previously shown to interact with Bax. The biological significance of this interaction was explored both in yeast and vertebrate cells an...

Modulation of Nr-13 antideath activity by peptide aptamers.

Archive ouverte | Nouvion, Al | CCSD

International audience. Tumor cells are characterized by deregulated proliferation and resistance to proapoptotic stimuli. The Bcl-2 family of antiapoptotic proteins is overexpressed in a large number of chemoresist...

Nrh, a human homologue of Nr-13 associates with Bcl-Xs and is an inhibitor of apoptosis

Archive ouverte | Aouacheria, A. | CCSD

International audience. In search of human homologues of the anti-apoptotic protein Nr-13, we have characterized a human EST clone that potentially encodes a protein, which is the closest homologue of Nr-13 among th...

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