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The p76 Rb and p100 Rb truncated forms of the Rb protein exert antagonistic roles on cell death regulation in human cell lines

Archive ouverte | Le Floch, Nathalie | CCSD

International audience. Several caspase-cleaved forms of the retinoblastoma protein have been described. Here, we compared the effect of full-length Rb versus the truncated p76 Rb and p100 Rb proteins on cell death ...

Mitochondrial p53 mediates a transcription-independent regulation of cell respiration and interacts with the mitochondrial F₁F₀-ATP synthase

Archive ouverte | Bergeaud, Marie | CCSD

International audience. We and others previously reported that endogenous p53 can be located at mitochondria in the absence of stress, suggesting that p53 has a role in the normal physiology of this organelle. The a...

zVAD-fmk upregulates caspase-9 cleavage and activity in etoposide-induced cell death of mouse embryonic fibroblasts

Archive ouverte | Rodríguez-Enfedaque, Aida | CCSD

International audience. Keywords: Caspase-9 zVAD-fmk p53-dependent cell death Mouse embryonic fibroblast Caspases are key effectors of programmed cell death. Down-and up-regulation of their activity are involved in ...

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