Changing of hepatitis C virus genotype patterns in France at the beginning of the third millenium: The GEMHEP GenoCII Study

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Payan, C. | Roudot-Thoraval, F. | Marcellin, P. | Bled, N. | Duverlie, G. | Fouchard-Hubert, I. | Trimoulet, P. | Couzigou, P. | Cointe, D. | Chaput, C. | Henquell, C. | Abergel, A. | Pawlotsky, J. M. | Hezode, C. | Coudé, M. | Blanchi, A. | Alain, Sophie | Loustaud-Ratti, Véronique | Chevallier, P. | Trepo, C. | Gerolami, V. | Portal, I. | Halfon, P. | Bourlière, M. | Bogard, M. | Plouvier, E. | Laffont, C. | Agius, G. | Silvain, C. | Brodard, V. | Thiefin, G. | Buffet-Janvresse, C. | Riachi, G. | Grattard, F. | Bourlet, T. | Stoll-Keller, F. | Doffoel, M. | Izopet, Jacques | Barange, K. | Martinot-Peignoux, M. | Branger, M. | Rosenberg, A. | Sogni, P. | Chaix, Marie-Laure | Pol, S. | Thibault, Valérie | Opolon, P. | Charrois, A. | Serfaty, L. | Fouqueray, B. | Grange, J. D. | Lefrère, J. J. | Lunel-Fabiani, F.

Edité par CCSD ; Wiley-Blackwell -

International audience. This cross-sectional study aimed to investigate, during a short period between 2000 and 2001, in a large population of patients with chronic hepatitis C, the epidemiological characteristics of hepatitis C virus (HCV) genotypes in France. Data from 26 referral centres, corresponding to 1769 patients with chronic hepatitis C were collected consecutively during a 6-month period. HCV genotyping in the 5'-non-coding region (NCR) was performed in each center using the line probe assay (LiPA, in 63% of cases), sequencing (25%) or primer-specific polymerase chain reaction (PCR) (12%). HCV genotypes 1a, 1b, 2, 3, 4, 5, non-subtyped 1 and mixed infection were found in 18, 27, 9, 21, 9, 3, 11 and 1% of our population, respectively. HCV genotype distribution was associated with gender, age, source and duration of infection, alanine aminotransferase (ALT) levels, cirrhosis, alcohol consumption, hepatitis B virus (HBV) and human immunodeficiency virus (HIV) coinfection. In multivariate analysis, only the source of infection was the independent factor significantly associated with genotype (P = 0.0001). In conclusion, this study shows a changing pattern of HCV genotypes in France, with i.v. drug abuse as the major risk factor, an increase of genotype 4, and to a lesser extent 1a and 5, and a decrease of genotypes 1b and 2. The modification of the HCV genotype pattern in France in the next 10 years may require new therapeutic strategies, and further survey studies.

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