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MOLECULAR REGULATION AND PHARMACOLOGY OF PACEMAKER CHANNELS

Archive ouverte | Bois, Patrick | CCSD

(IF : 4,868). International audience. The spontaneous activity of cardiac tissue originates in specialized pacemaker cells in the sino-atrial node that generate autonomous rhythmic electrical impulses. A number of r...

A distinct de novo expression of Nav1.5 sodium channels in human atrial fibroblasts differentiated into myofibroblasts.

Archive ouverte | Chatelier, Aurélien | CCSD

International audience. Fibroblasts play a major role in heart physiology. They are at the origin of the extracellular matrix renewal and production of various paracrine and autocrine factors. In pathological condit...

Functional characterization of a Ca 2+ ‐activated non‐selective cation channel in human atrial cardiomyocytes

Archive ouverte | Guinamard, Romain | CCSD

International audience. Cardiac arrhythmias, which occur in a wide variety of conditions where intracellular calcium is increased, have been attributed to the activation of a transient inward current (Iti). Iti is t...

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