A correlative study of ultrasound with serology in an area in China co-endemic for human alveolar and cystic echinococcosis.

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Yang, Y. R. | Craig, P. S. | Ito, A. | Vuitton, D. A. | Giraudoux, P. | Sun, T. | Williams, G. M. | Huang, Z. | Li, Zhenyu | Wang, Y. | Teng, J. | Li, Y. | Huang, L. | Wen, H. | Jones, M. K. | Mcmanus, D. P.

Edité par CCSD ; Wiley-Blackwell -

International audience. We correlated ultrasound (US) imaging classifications for human alveolar echinococcosis (AE) and cystic echinococcosis (CE) with serology (ELISA and immunoblotting (IB) incorporating native and recombinant/purified echinococcal antigens) in community surveys (2001-2003) and follow-up (2002 and 2003) of US-confirmed cases in Ningxia, China. One hundred and seventy-one cases (96 with AE, 75 with CE) were identified; of these, US classification and serological data were obtained for 142 and 112 cases, respectively. Seropositive-rates increased in CE patients with highly viable unilocular cyst lesions (Types CL, CE 1 or CE 2) to degenerating primary lesions (CE 3), but then decreased in subjects with inactive (CE 4) or dead (CE 5) cysts. In contrast, there was a constant increase in seropositivity from the early (P1, P2) to the advanced stages (P3, P4) with AE cases. For US-confirmed cases, follow-up by US combined with serology is invaluable for studying the clinical progression of echinococcosis and for detecting recurrent cysts or reinfection post-treatment.

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