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Effect of pyridoxine on the inhibition by dexamethasone of murine erythroleukemia cell differentiation.

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Osborne, Howard Beverley

Edité par CCSD ; Elsevier -

International audience. Glucocorticoids are known to inhibit the induced differentiation of murine erythroleukemia cells. I show here that the binding of glucocorticoid receptors to the intact nuclei of these cells is reduced by exogenous extracellular pyridoxine (1-4 mM). This reduction of glucocorticoid-receptor binding did not abrogate the inhibition by dexamethasone of the induced differentiation.

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