TRAF4, the unique family member.

0 avis

TRAF4, the unique family member.

Archive ouverte

Kedinger, Valérie | Rio, Marie-Christine

The fourth member of the TRAF protein family (TRAF4) presents several characteristics that distinguish it from the other members of the family. These characteristics concern the primary sequence of the protein, a strong evolutionary conservation, and a tightly regulated physiological expression during development. The subcellular localization of TRAF4 is controversial as it has been detected at the cell membrane, in the cytoplasm and in the nucleus. Using mouse and fly models, it has been established that TRAF4 is a key molecule in diverse ontogenic processes, particularly in the nervous system. However, the molecular mechanisms of action of TRAF4 remain evasive as it was found to interact with diverse types of proteins, leading either to pro-apoptotic or anti-apoptotic functions. Finally, few studies implicated TRAF4 in human diseases.

Langue: en

Indexation

Consulter en ligne

Consulter le document

Suggestions

Du même auteur

Impaired neural tube closure, axial skeleton malformations, and tracheal ring disruption in TRAF4-deficient mice

Archive ouverte | Régnier, Catherine H. | CCSD

International audience. TRAF4 belongs to the tumor necrosis factor receptor-associated factor (TRAF) family of proteins but, unlike other family members, has not yet been clearly associated to any specific receptor ...

Spatial and temporal distribution of the traf4 genes during zebrafish development.

Archive ouverte | Kedinger, Valérie | CCSD

International audience. The tumor necrosis factor-associated factor 4 (TRAF4) is a particular member of the TRAF protein family since it is not involved in the Tumor Necrosis Factor (TNF) and Interleukin-1 (IL-1) si...