Discovery of compounds blocking the proliferation of Toxoplasma gondii and Plasmodium falciparum in a chemical space based on piperidinyl-benzimidazolidinone analogs.

Archive ouverte | Saïdani, Nadia | CCSD

International audience. A piperidinyl-benzimidazolidinone scaffold has been found in the structure of different inhibitors of membrane glycerolipid metabolism, acting on enzymes manipulating diacylglycerol or phosph...

Compounds with antiparasitic activity, applications thereof to the treatment of infectious diseases caused by apicomplexans

Archive ouverte | Deligny, Michael | CCSD

Enhanced antimalarial activity of novel synthetic aculeatin derivatives.

Archive ouverte | Peuchmaur, Marine | CCSD

International audience. We report the design, synthesis, and in vitro evaluation of novel polyspirocyclic structures, inspired by the antimalarial natural products, the aculeatins. A divergent synthetic strategy was...