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Ionic mechanisms involved in the nodal swelling of myelinated axons caused by marine toxins.

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Benoit, Evelyne | Mattei, César | Ouanounou, Gilles | Meunier, Frédéric A. | Suput, Dusan | Le Gall, Frederic | Marquais, Michel | Dechraoui, Marie y | Molgó, Jordi

Edité par CCSD ; Springer Verlag (Germany) -

This review describes the ionic mechanisms involved in the nodal swelling of frog myelinated axons caused by specific marine neurotoxins (ciguatoxins, brevetoxins, Conus consors toxin and equinatoxin-II), analysed using confocal laser scanning microscopy. We have focussed on toxins that either target neuronal voltage-dependent Na+ channels, or that form cation-selective pores and indirectly affect the functioning of the Na(+)-Ca(++)exchanger.

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