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Cajal body-specific small nuclear RNAs: a novel class of 2 '-O-methylation and pseudouridylation guide RNAs

Archive ouverte | Darzacq, X. | CCSD

International audience. Cajal (coiled) bodies are conserved subnuclear organelles that are present in the nucleoplasm of both animal and plant cells. Although Cajal bodies were first described nearly 100 years ago, ...

A Cajal body-specific pseudouridylation guide RNA is composed of two box H/ACA snoRNA-like domains

Archive ouverte | Kiss, A. M. | CCSD

International audience. Site-specific post-transcriptional conversion of uridines to pseudouridine in ribosomal RNAs and small nuclear RNAs (snRNAs) is directed by guide RNAs which possess the conserved box H and AC...

Biogenesis and intranuclear trafficking of human box C/D and H/ACA RNPs.

Archive ouverte | Kiss, T. | CCSD

Box C/D and H/ACA snoRNAs represent two abundant groups of small noncoding RNAs. The majority of box C/D and H/ACA snoRNAs function as guide RNAs in the site-specific 2'-O-methylation and pseudouridylation of rRNAs, respectively. ...

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