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Tag-mass: Specific molecular imaging of transcriptome and proteome by mass spectrometry based on photocleavable tag

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Lemaire, R. | Stauber, J. | Wisztorski, M. | van Camp, C. | Desmons, A. | Deschamps, M. | Proess, G. | Rudlof, I. | S. Woods, A. | Day, R. | Salzet, M. | Fournier, I.

Edité par CCSD ; American Chemical Society -

International audience. MALDI tissue imaging of tissues has become a promising technique for tracking biomarkers while determining their location and structural characterization. We have now developed specific targeting probes (oligonucleotides, antibodies), named Tag-Mass. This approach is based on probes modified with a photocleavable linker coupled with a tag cleaved and detected using mass spectrometry. Tag-Mass development is the key for a rapid, sensitive, and accurate approach to correlate levels of expression of different mRNA or proteins in diseases.

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