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Alzheimer disease specific phosphoepitopes of Tau interfere with assembly of tubulin but not binding to microtubules.

Archive ouverte | Amniai, Laziza | CCSD

International audience. In Alzheimer disease (AD)-affected neurons, the Tau protein is found in an aggregated and hyperphosphorylated state. A common hypothesis is that Tau hyperphosphorylation causes its dissociati...

Towards understanding the phosphorylation code of tau.

Archive ouverte | Lippens, Guy | CCSD

International audience. We describe our efforts to combine in vitro enzymatic reactions with recombinant kinases to phosphorylate the neuronal tau protein, and NMR spectroscopy to unravel the resulting phosphorylati...

NMR Investigation of the Interaction between the Neuronal Protein Tau and the Microtubules.

Archive ouverte | Sillen, Alain | CCSD

Whereas the interaction between Tau and the microtubules has been studied in great detail both by macroscopic techniques (cosedimentation, cryo-electron microscopy, and fluorescence spectroscopy) using the full-length protein or b...

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