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Cytotoxic and antiplasmodial xanthones from Pentadesma butyracea

Archive ouverte | Zelefack, F. | CCSD

International audience. Four new xanthones, butyraxanthones A?D (1?4), were isolated from the stem bark of Pentadesma butyracea, together with six known xanthones (5?10) and a triterpenoid (lupeol). The structures o...

A new nonpolar N-hydroxy imidazoline lead compound with improved activity in a murine model of late-stage Trypanosoma brucei brucei infection is not cross-resistant with diamidines

Archive ouverte | Ríos Martínez, C.H. | CCSD

International audience. Treatment of late-stage sleeping sickness requires drugs that can cross the blood-brain barrier (BBB) to reach the parasites located in the brain. We report here the synthesis and evaluation ...

Aminoglycoside-quinacridine conjugates : towards recognition of the P6.1 element of telomerase RNA

Archive ouverte | Kaiser, M. | CCSD

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