Suggestions

Du même auteur

Tailoring T-cell receptor signals by proximal negative feedback mechanisms.

Archive ouverte | Acuto, Oreste | CCSD

International audience. The T-cell receptor (TCR) signalling machinery is central in determining the response of a T cell (establishing immunity or tolerance) following exposure to antigen. This process is made diff...

In the immune synapse, ZAP-70 controls T cell polarization and recruitment of signaling proteins but not formation of the synaptic pattern.

Archive ouverte | Blanchard, Nicolas | CCSD

Recognition by T cells of their ligands at the surface of antigen-presenting cells (APCs) leads to T cell activation, polarization of the T cell toward the APC, and formation of an immune synapse. Using ZAP-70-deficient T cells ex...

Cell polarity regulators, multifunctional organizers of lymphocyte activation and function

Archive ouverte | Mastrogiovanni, Marta | CCSD

International audience. Cell polarity regulators are ubiquitous, evolutionary conserved multifunctional proteins. They contain a variety of protein-protein interaction domains endowing them the capacity to interact ...

Chargement des enrichissements...