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Membrane-cytoskeleton interactions during the formation of the immunological synapse and subsequent T-cell activation.

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Das, Vincent | Nal, Béatrice | Roumier, Anne | Meas-Yedid, Vannary | Zimmer, Christophe | Olivo-Marin, Jean-Christophe | Roux, Pascal | Ferrier, Pierre | Dautry-Varsat, Alice | Alcover, Andrés

Edité par CCSD ; Wiley -

Upon antigen recognition, T cells undergo substantial membrane and cytoskeletal rearrangements that lead to the formation of the immunological synapse and are necessary for subsequent T-cell activation. However, little is known about how membrane and cytoskeletal molecules interact during these processes. Here we discuss the involvement of the membrane-microfilament linker ezrin. We propose that ezrin is a component of the cytoskeleton-mediated architecture of the immunological synapse that plays a role in T-cell receptor clustering, protein kinase C theta translocation and intracellular signaling.

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