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A delta-conotoxin from Conus ermineus venom inhibits inactivation in vertebrate neuronal Na+ channels but not in skeletal and cardiac muscles.

Archive ouverte | Barbier, Julien | CCSD

We have isolated delta-conotoxin EVIA (delta-EVIA), a conopeptide in Conus ermineus venom that contains 32 amino acid residues and a six-cysteine/four-loop framework similar to that of previously described omega-, delta-, microO-,...

A new omega-conotoxin that targets N-type voltage-sensitive calcium channels with unusual specificity.

Archive ouverte | Favreau, Philippe | CCSD

A new specific voltage-sensitive calcium channel (VSCC) blocker has been isolated from the venom of the fish-hunting cone snail Conus consors. This peptide, named omega-Ctx CNVIIA, consists of 27 amino acid residues folded by 3 di...

Scorpion alpha and alpha-like toxins differentially interact with sodium channels in mammalian CNS and periphery.

Archive ouverte | Gilles, Nicolas | CCSD

Scorpion alpha-toxins from Leiurus quinquestriatus hebraeus, LqhII and LqhIII, are similarly toxic to mice when administered by a subcutaneous route, but in mouse brain LqhII is 25-fold more toxic. Examination of the two toxins ef...

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