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Fibroblast Growth Factor 1 inhibits p53-dependent apoptosis in PC12 cells

Archive ouverte | Bouleau, S. | CCSD

Transcriptional repression by p53 promotes a Bcl-2-insensitive and mitochondria-independent pathway of apoptosis

Archive ouverte | Godefroy, Nelly | CCSD

International audience. p53 can induce apoptosis in various ways including transactivation, transrepression and transcription-independent mechanisms. What determines the choice between them is poorly understood. In ...

Caspase-9 can antagonize p53-induced apoptosis by generating a p76Rb truncated form of Rb

Archive ouverte | Lemaire, Christophe | CCSD

International audience. The tumor suppressor Rb (retinoblastoma protein) is known to regulate p53-dependent apoptosis, but the mechanisms involved are unclear. In a rat fibroblast model, we previously observed that ...

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