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The drosophila Bcl-2 family protein Debcl is targeted to the proteasome by the b-TrCP homologue slimb

Archive ouverte | Colin, Jessie | CCSD

International audience. The ubiquitin-proteasome system is one of the main proteolytic pathways. It inhibits apoptosis by degrading pro-apoptotic regulators, such as caspases or the tumor suppressor p53. However, it...

Down-regulation of actin genes precedes microfilament network disruption and actin cleavage during p53 mediated-apoptosis

Archive ouverte | Guenal, Isabelle | CCSD

International audience

Screening of suppressors of bax-induced cell death identifies glycerophosphate oxidase-1 as a mediator of debcl-induced apoptosis in Drosophila

Archive ouverte | Colin, Jessie | CCSD

International audience. Members of the Bcl-2 family are key elements of the apoptotic machinery. In mammals, this multigenic family contains about twenty members, which either promote or inhibit apoptosis. We have p...

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