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SCRG1, a potential marker of autophagy in transmissible spongiform encephalopathies.

Archive ouverte | Dron, Michel | CCSD

International audience. The Scrg1 gene was initially discovered as one of the genes upregulated in transmissible spongiform encephalopathies (TSE). Scrg1 encodes a highly conserved, cysteine-rich protein expressed p...

Scrg1 is induced in TSE and brain injuries, and associated with autophagy

Archive ouverte | Dron, Michel | CCSD

International audience. We have previously identified Scrg1, a gene with increased cerebral mRNA levels in transmissible spongiform encephalopathies (TSE) such as scrapie, bovine spongiform encephalopathy and Creutz...

Infection by ME7 prion is not modified in transgenic mice expressing the yeast chaperone Hsp104 in neurons

Archive ouverte | Dandoy-Dron, Françoise | CCSD

International audience. The Hsp104 chaperone induces thermo-tolerance in yeast and rescues proteins trapped in aggregates. In this study, we showed that xenogenic expression of Hsp104 dramatically increased the viab...

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