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NEDD1-dependent recruitment of the gamma-tubulin ring complex to the centrosome is necessary for centriole duplication and spindle assembly

Archive ouverte | Haren, Laurence | CCSD

The centrosome is the major microtubule organizing structure in somatic cells. Centrosomal microtubule nucleation depends on the protein gamma-tubulin. In mammals, gamma-tubulin associates with additional proteins into a large com...

Assembly of Gamma-Tubulin Ring Complexes: Implications for Cell Biology and Disease

Archive ouverte | Remy, Marie-Hélène | CCSD

International audience. Microtubules are among the main constituents of the cytoskeleton. They are assembled from dimers of alpha- and beta-tubulin. This assembly occurs preferentially at organizing centers such as ...

Crystal structure of γ-tubulin complex protein GCP4 provides insight into microtubule nucleation

Archive ouverte | Guillet, Valérie | CCSD

International audience. Microtubule nucleation in all eukaryotes involves g-tubulin small complexes (gTuSCs) that comprise two molecules of g-tubulin bound to g-tubulin complex proteins (GCPs) GCP2 and GCP3. In many...

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