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The JAK/STAT3 pathway is a common inducer of astrocyte reactivity in Alzheimer's and Huntington's diseases

Archive ouverte | Ben Haim, L. | CCSD

International audience. Astrocyte reactivity is a hallmark of neurodegenerative diseases (ND), but its effects on disease outcomes remain highly debated. Elucidation of the signaling cascades inducing reactivity in ...

Loss of the thyroid hormone-binding protein Crym renders striatal neurons more vulnerable to mutant huntingtin in Huntington's disease

Archive ouverte | Francelle, L. | CCSD

International audience. The mechanisms underlying preferential atrophy of the striatum in Huntington's disease (HD) are unknown. One hypothesis is that a set of gene products preferentially expressed in the striatum...

2010001M06rik (St102) protects striatal neurons against an N-terminal fragmentof mutant huntingtin in vivo

Archive ouverte | Brouillet, E. | CCSD

International audience. The mechanisms underlying the preferential vulnerability of striatal neurons to mutant Huntingtin (mHtt) in Huntington's disease (HD) remain unknown. Our hypothesis, supported by recent publi...

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