Pseudoguanolide sesquiterpene lactones from Veroniopsis caudata and their in vitro antiplasmodial activities.

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Ramanandraibe, V. | Martin, M.-T. | Rakotondramanana, D.L. | Mambu, L. | Ramanitrahasimbola, D. | Mabaïed, M. | Rasoanoivo, P. | Grellier, P. | Frappier, F.

Edité par CCSD ; American Chemical Society -

Two new helenanolide sesquiterpene lactones, 1 and 2, as well as one known related structure, 11α,13-dihydrohelenalin-[2-(1-hydroxyethyl)acrylate] (3), together with 4′-β-D-O-glucopyranosyl-luteolin and ethyl 2,5-dihydroxycinnamate were isolated from an ethyl acetate extract of leaves of Vernoniopsis caudata with potent antiplasmodial activity (IC50 1.6 μg/mL) in a preliminary biological screen. The structures of the new compounds were determined by spectroscopic techniques. The three sesquiterpene lactones 1-3 displayed strong in vitro antiplasmodial activity, with IC 50 values of 1, 0.19, and 0.41 μM, respectively. However, these compounds also exhibited considerable cytotoxicity on KB cells (IC50 < 1 μM in each case). © 2005 American Chemical Society and American Society of Pharmacognosy.

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