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Sequential protein association with nascent 60S ribosomal particles

Archive ouverte | Saveanu, Cosmin | CCSD

International audience. Ribosome biogenesis in eukaryotes depends on the coordinated action of ribosomal and nonribosomal proteins that guide the assembly of preribosomal particles. These intermediate particles foll...

Specific Role for Yeast Homologs of the Diamond Blackfan Anemia associated Rps19 Protein in Ribosome Synthesis

Archive ouverte | Léger-Silvestre, Isabelle | CCSD

Approximately 25% of cases of Diamond Blackfan anemia, a severe hypoplastic anemia, are linked to heterozygous mutations in the gene encoding ribosomal protein S19 that result in haploinsufficiency for this protein. Here we show t...

Impact of two neighbouring ribosomal protein clusters on biogenesis factor binding and assembly of yeast late small ribosomal subunit precursors

Archive ouverte | Linnemann, Jan | CCSD

International audience. Many of the small ribosomal subunit proteins are required for the stabilisation of late small ribosomal subunit (SSU) precursors and for final SSU rRNA processing in S. cerevisiae. Among them...

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