Genome-wide association study identifies multiple risk loci for renal cell carcinoma
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Scelo, Ghislaine | Purdue, Mark, P | Brown, Kevin, M | Johansson, Mattias | Wang, Zhaoming | Eckel-Passow, Jeanette, E | Ye, Yuanqing | Hofmann, Jonathan, N | Choi, Jiyeon | Foll, Matthieu | Gaborieau, Valerie | Machiela, Mitchell, J | Colli, Leandro, M | Li, Peng | Sampson, Joshua, N | Abedi-Ardekani, Behnoush | Besse, Celine | Blanche, Helene | Boland, Anne | Burdette, Laurie | Chabrier, Amelie | Durand, Geoffroy | Le Calvez-Kelm, Florence | Prokhortchouk, Egor | Robinot, Nivonirina | Skryabin, Konstantin, G | Wozniak, Magdalena, B | Yeager, Meredith | Basta-Jovanovic, Gordana | Dzamic, Zoran | Foretova, Lenka | Holcatova, Ivana | Janout, Vladimir | Mates, Dana | Mukeriya, Anush | Rascu, Stefan | Zaridze, David | Bencko, Vladimir | Cybulski, Cezary | Fabianova, Eleonora | Jinga, Viorel | Lissowska, Jolanta | Lubinski, Jan | Navratilova, Marie | Rudnai, Peter | Szeszenia-Dabrowska, Neonila | Benhamou, Simone | Cancel-Tassin, Geraldine | Cussenot, Olivier | Baglietto, Laura | Boeing, Heiner | Khaw, Kay-Tee | Weiderpass, Elisabete | Ljungberg, Borje | Sitaram, Raviprakash, T | Bruinsma, Fiona | Jordan, Susan, J | Severi, Gianluca | Winship, Ingrid | Hveem, Kristian | Vatten, Lars, J | Fletcher, Tony | Koppova, Kvetoslava | Larsson, Susanna, C | Wolk, Alicja | Banks, Rosamonde, E | Selby, Peter, J | Easton, Douglas, F | Pharoah, Paul | Andreotti, Gabriella | Freeman, Laura, E Beane | Koutros, Stella | Albanes, Demetrius | Männistö, Satu | Weinstein, Stephanie | Clark, Peter, E | Edwards, Todd, L | Lipworth, Loren | Gapstur, Susan, M | Stevens, Victoria, L | Carol, Hallie | Freedman, Matthew, L | Pomerantz, Mark, M | Cho, Eunyoung | Kraft, Peter | Preston, Mark, A | Wilson, Kathryn, M | Michael Gaziano, J. | Sesso, Howard, D | Black, Amanda | Freedman, Neal, D | Huang, Wen-Yi | Anema, John, G | Kahnoski, Richard, J | Lane, Brian, R | Noyes, Sabrina, L | Petillo, David | Teh, Bin, Tean | Peters, Ulrike | White, Emily | Anderson, Garnet, L | Johnson, Lisa | Luo, Juhua | Buring, Julie | Lee, I-Min | Chow, Wong-Ho | Moore, Lee, E | Wood, Christopher | Eisen, Timothy | Henrion, Marc | Larkin, James | Barman, Poulami | Leibovich, Bradley, C | Choueiri, Toni, K | Mark Lathrop, G. | Rothman, Nathaniel | Deleuze, Jean-Francois | Mckay, James, D | Parker, Alexander, S | Wu, Xifeng | Houlston, Richard, S | Brennan, Paul | Chanock, Stephen, J
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Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, P =3.1 × 10$^{−10}$ ), 3p22.1 (rs67311347, P =2.5 × 10$^{−8}$ ), 3q26.2 (rs10936602, P =8.8 × 10$^{−9}$ ), 8p21.3 (rs2241261, P =5.8 × 10$^{−9}$ ), 10q24.33-q25.1 (rs11813268, P =3.9 × 10$^{−8}$ ), 11q22.3 (rs74911261, P =2.1 × 10$^{−10}$ ) and 14q24.2 (rs4903064, P =2.2 × 10$^{−24}$ ). Expression quantitative trait analyses suggest plausible candidate genes at these regions that may contribute to RCC susceptibility.
