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Use of adeno-associated virus-mediated delivery of mutant huntingtin to study the spreading capacity of the protein in mice and non-human primates

Archive ouverte | Maxan, Alexander | CCSD

International audience. In order to model various aspects of Huntington's disease (HD) pathology, in particular protein spread, we administered adeno-associated virus (AAV) expressing green fluorescent protein (GFP)...

Treatment with Tau fibrils impact Huntington's disease-related phenotypes in cell and mouse models

Archive ouverte | Salem, Shireen | CCSD

International audience. There is now compelling evidence for the presence of pathological forms of Tau in tissues of both patients and animal models of Huntington's disease (HD). While the root cause of this illness...

Evidence for the spread of human-derived mutant huntingtin protein in mice and non-human primates

Archive ouverte | Gosset, Philippe | CCSD

International audience. In recent years, substantial evidence has emerged to suggest that spreading of pathological proteins contributes to disease pathology in numerous neurodegenerative disorders. Work from our la...

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