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Heritability of surface area and cortical thickness: a comparison between the Human Connectome Project and the UK Biobank dataset

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Le Guen, Yann | Karkar, Slim | Grigis, Antoine | Philippe, Cathy | Mangin, Jean-François | Frouin, Vincent

Edité par CCSD -

International audience. Heritability of the regional thickness/surface in human cortex is established. Yet the estimates vary substantially depending on cohorts or the information they are derived from: pedigree or genotyping. Here we present three heritability studies of the cortex phenotype in two cohorts showing: i) both pedigree and genotyping or ii) genotyping only. We obtained clearly correlated heritability values between studies with a shift appearing between cohorts. Spatial pattern of heritability remains highly consistent across cohorts

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