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Absence of co-localization between pathovar-associated virulence factors and extended-spectrum β-lactamase (bla CTX-M) genes on a single plasmid
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International audience. Extended-spectrum b-lactamases (ESBLs) were reported in virulent food-borne Escherichia coli clones,and numerous genes encoding ESBLs and virulence factors (VFs) are plasmid-mediated. We investigatedthe plasmidic co-localization of ESBL genes and pathovar-associated VF genes isolated in 18 E. coli isolatesfrom faecal samples of diseased cattle. From the rare ESBL-producing E. coli among the various pathovars,no plasmid co-localization was found between VF and blaCTX-M genes on a single plasmid. However, a linkbetween replicon types and VFs was highlighted: EspP was associated with IncFIB and ToxB with IncB/O.Associations of IncF alleles to VF or CTX-M-types were also identified: CS31A was linked to the alleleFIB38 and CTX-M-14 to IncFII2. Also, as illustrated here, IncFII and IncFIB were carried by two differentplasmids in a single cell.
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