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Crossing and zipping: molecular duties of the ZMM proteins in meiosis

Archive ouverte | Pyatnitskaya, Alexandra | CCSD

International audience. Accurate segregation of homologous chromosomes during meiosis depends on the ability of meiotic cells to promote reciprocal exchanges between parental DNA strands, known as crossovers (COs). ...

The Zip4 protein directly couples meiotic crossover formation to synaptonemal complex assembly

Archive ouverte | Pyatnitskaya, Alexandra | CCSD

International audience. Meiotic recombination is triggered by programmed double-strand breaks (DSBs), a subset of these being repaired as crossovers, promoted by eight evolutionarily conserved proteins, named ZMM. C...

E3 ligase Hei10: a multifaceted structure-based signaling molecule with roles within and beyond meiosis.

Archive ouverte | de Muyt, Arnaud | CCSD

International audience. Human enhancer of invasion-10 (Hei10) mediates meiotic recombination and also plays roles in cell proliferation. Here we explore Hei10's roles throughout the sexual cycle of the fungus Sordar...

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