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Sister chromatid cohesion halts DNA loop expansion

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Bastié, Nathalie | Chapard, Christophe | Cournac, Axel | Nejmi, Sanae | Mboumba, Henri | Gadal, Olivier | Thierry, Agnès | Beckouët, Frederic | Koszul, Romain

Edité par CCSD ; Cell Press -

International audience. Eukaryotic genomes are folded into DNA loops mediated by structural maintenance of chromosomes (SMC) complexes such as cohesin, condensin, and Smc5/6. This organization regulates different DNA-related processes along the cell cycle, such as transcription, recombination, segregation, and DNA repair. During the G2 stage, SMC-mediated DNA loops coexist with cohesin complexes involved in sister chromatid cohesion (SCC). However, the articulation between the establishment of SCC and the formation of SMC-mediated DNA loops along the chromatin remains unknown. Here, we show that SCC is indeed a barrier to cohesin-mediated DNA loop expansion along G2/M Saccharomyces cerevisiae chromosomes.

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