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GATA-3 Promotes Maturation, IFN-γ Production, and Liver-Specific Homing of NK Cells

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Samson, Sandrine, I | Richard, Odile | Tavian, Manuela | Ranson, Thomas | Vosshenrich, Christian A. J. | Colucci, Francesco | Buer, Jan | Grosveld, Frank | Godin, Isabelle | Di Santo, James, P

Edité par CCSD ; Elsevier -

International audience. The GATA-3 transcription factor has a determinant role in T cell specification and is an essential mediator of T helper 2-type polarized immune responses. While both committed NK precursors and mature NK cells express GATA-3, a role of this transcription factor in murine NK cell differentiation is not known. We found that NK cells, in contrast to T cells, can be generated in the absence of GATA-3. However, while GATA-3 antagonizes IFN-gamma production in differentiating T cells, GATA-3-deficient NK cells paradoxically produced less IFN-gamma compared to control NK cells and failed to provide early protection in vivo against infection with Listeria monocytogenes. Surprisingly, GATA-3 was essential for NK cell homing to the liver. Our results suggest that GATA-3 promotes NK cell maturation and acts in this lineage to specify distinct effector phenotypes.

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