Assay for Hepatitis B Core-related Antigen Identify Patients With High Viral Load: Systematic Review and Meta-analysis of Individual Participant Data

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Yoshida, Kyoko | Desbiolles, Alice | Feldman, Sarah | Ahn, Sang Hoon | Alidjinou, Enagnon | Atsukawa, Masanori | Bocket, Laurence | Brunetto, Maurizia | Buti, Maria | Carey, Ivana | Caviglia, Gian Paolo | Chen, En-Qiang | Cornberg, Markus | Enomoto, Masaru | Honda, Masao | zu Siederdissen, Christoph Höner | Ishigami, Masatoshi | Janssen, Harry La | Maasoumy, Benjamin | Matsui, Takeshi | Matsumoto, Akihiro | Nishiguchi, Shuhei | Riveiro-Barciela, Mar | Takaki, Akinobu | Tangkijvanich, Pisit | Toyoda, Hidenori | van Campenhout, Margo Jh | Wang, Bo | Wei, Lai | Yang, Hwai-I | Yano, Yoshihiko | Yatsuhashi, Hiroshi | Yuen, Man-Fung | Tanaka, Eiji | Lemoine, Maud | Tanaka, Yasuhito | Shimakawa, Yusuke

Edité par CCSD ; WB Saunders -

International audience. Scale-up of tests and treatments is needed to eliminate hepatitis B virus (HBV) infection from resource-limited countries. However, access to nucleic acid tests that quantify HBV DNA, to determine treatment eligibility, is severely limited. We performed a systematic review and meta-analysis to assess the performance of the hepatitis B core-related antigen (HBcrAg) immunoassay, a low-cost (less than $15/assay) alternative to the nucleic acid test, to identify highly viremic patients, infected with any HBV genotype.

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