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Immunodominance of HLA-B27-restricted HIV KK10-specific CD8(+) T-cells is not related to naïve precursor frequency

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Iglesias, Maria Candela | Briceño, Olivia | Gostick, Emma | Moris, Arnaud | Meaudre, Céline | Price, David A. | Ungeheuer, Marie-Noelle | Saez-Cirion, Asier | Mallone, Roberto | Appay, Victor

Edité par CCSD ; Elsevier -

International audience. The factors that determine the immunodominance, efficacy and almost ubiquitous presence of CD8(+) T-cell responses to the HLA-B27-restricted HIV-1 p24 Gag-derived KK10 epitope remain to be fully elucidated. Here, we show that neither the precursor frequency nor the priming capacity of KK10-reactive CD8(+) T-cells within the naïve pool differ substantially in comparison to other specificities. These data implicate alternative mechanisms in the relative protection conferred by CD8(+) T-cell responses to this epitope.

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