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Arylsulfone-based HIV-1 non-nucleoside reverse transcriptase inhibitors.

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Famiglini, Valeria | Coluccia, Antonio | Brancale, Andrea | Pelliccia, Sveva | La Regina, Giuseppe | Silvestri, Romano

Edité par CCSD ; Future Science -

International audience. HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) represent one of the most significant classes of drugs for the treatment of AIDS/HIV infection. Over the past two decades several potent arylsulfone-based HIV-1 NNRTIs and related analogs have been developed. This review provides an essential overview of the structure-activity relationships of the arylsulfone-based HIV-1 NNRTIs. Furthermore, structural information useful for the design and development of new sulfur containing NNRTIs with enhanced antiretroviral activity against HIV-1 wild type and clinically relevant drug resistant HIV-1 mutant strains will be discussed.

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