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Lipidome determinants of maximal lifespan in mammals

Archive ouverte | Bozek, Katarzyna | CCSD

International audience. Maximal lifespan of mammalian species, even if closely related, may differ more than 10-fold, however the nature of the mechanisms that determine this variability is unresolved. Here, we asse...

INK4 locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoform

Archive ouverte | Tian, Xiao | CCSD

International audience. The naked mole rat ( Heterocephalus glaber ) is a long-lived and tumor-resistant rodent. Tumor resistance in the naked mole rat is mediated by the extracellular matrix component hyaluronan of...

DNA methylation networks underlying mammalian traits

Archive ouverte | Haghani, Amin | CCSD

International audience. Using DNA methylation profiles ( n = 15,456) from 348 mammalian species, we constructed phyloepigenetic trees that bear marked similarities to traditional phylogenetic ones. Using unsupervise...

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