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Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice

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Yalcin, Binnaz | Willis-Owen, Saffron, a G | Fullerton, Jan | Meesaq, Anjela | Deacon, Robert, M | Rawlins, J, Nicholas P | Copley, Richard, R | Morris, Andrew, P | Flint, Jonathan | Mott, Richard

Edité par CCSD ; Nature Publishing Group -

International audience. Here we present a strategy to determine the genetic basis of variance in complex phenotypes that arise from natural, as opposed to induced, genetic variation in mice. We show that a commercially available strain of outbred mice, MF1, can be treated as an ultrafine mosaic of standard inbred strains and accordingly used to dissect a known quantitative trait locus influencing anxiety. We also show that this locus can be subdivided into three regions, one of which contains Rgs2, which encodes a regulator of G protein signaling. We then use quantitative complementation to show that Rgs2 is a quantitative trait gene. This combined genetic and functional approach should be applicable to the analysis of any quantitative trait.

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