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Monitoring of the Sensitivity In Vivo of Plasmodium falciparum to Artemether-Lumefantrine in Mali

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Diarra, Modibo | Coulibaly, Drissa | Tapily, Amadou | Guindo, Boureima | Sanogo, Koualy | Koné, Diakalia | Koné, Youssouf | Koné, Karim | Bathily, Aboudramane | Yattara, Oumar | Thera, Mahamadou, A | Dicko, Alassane | Djimdé, Abdoulaye, A | Sagara, Issaka

Edité par CCSD ; MDPI -

International audience. In Mali, since 2007, artemether-lumefantrine has been the first choice against uncomplicated malaria. Despite its effectiveness, a rapid selection of markers of resistance to partner drugs has been documented. This work evaluated the treatment according to the World Health Organization's standard 28-day treatment method. The primary endpoint was the clinical and parasitological response corrected by a polymerase chain reaction. It was more than 99.9 percent, the proportion of patients with anemia significantly decrease compared to baseline (p < 0.001), and no serious events were recorded. Plasmodium falciparum remains sensitive to artemether-lumefantrine in Mali.

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