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Dynamic full-field optical coherence tomography: 3D live-imaging of retinal organoids

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Scholler, Jules | Groux, Kassandra | Goureau, Olivier | Sahel, José-Alain | Fink, Mathias | Reichman, Sacha | Boccara, Claude | Grieve, Kate

Edité par CCSD ; Nature Publishing Group -

International audience. Abstract Optical coherence tomography offers astounding opportunities to image the complex structure of living tissue but lacks functional information. We present dynamic full-field optical coherence tomography as a technique to noninvasively image living human induced pluripotent stem cell-derived retinal organoids. Coloured images with an endogenous contrast linked to organelle motility are generated, with submicrometre spatial resolution and millisecond temporal resolution, creating a way to identify specific cell types in living tissue via their function.

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