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DOK1 and DOK2 regulate CD8 T cell signaling and memory formation without affecting tumor cell killing

Archive ouverte | Laletin, Vladimir | CCSD

International audience. Targeting intracellular inhibiting proteins has been revealed to be a promising strategy to improve CD8 + T cell anti-tumor efficacy. Here, we are focusing on intracellular inhibiting protein...

DOK1 and DOK2 regulate CD8 T cell signaling and memory formation without affecting tumor cell killing

Archive ouverte | Laletin, Vladimir | CCSD

International audience. Abstract Targeting intracellular inhibiting proteins has been revealed to be a promising strategy to improve CD8 + T cell anti-tumor efficacy. Here, we are focusing on intracellular inhibitin...

Negative intracellular regulators of T-cell receptor (TCR) signaling as potential antitumor immunotherapy targets

Archive ouverte | Laletin, Vladimir | CCSD

International audience. Immunotherapy strategies aim to mobilize immune defenses against tumor cells by targeting mainly T cells. Co‐inhibitory receptors or immune checkpoints (ICPs) (such as PD-1 and CTLA-4) can li...

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