Hepatic molecular signatures highlight the sexual dimorphism of Non-Alcoholic SteatoHepatitis (NASH)

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Vandel, Jimmy | Dubois-Chevalier, Julie | Gheeraert, Celine | Derudas, Bruno | Raverdy, Violetta | Thuillier, Dorothée | van Gaal, Luc | Francque, Sven | Pattou, Francois | Staels, Bart | Eeckhoute, Jérôme | Lefebvre, Philippe

Edité par CCSD ; Wiley-Blackwell -

International audience. Non-Alcoholic SteatoHepatitis (NASH) is considered as a pivotal stage in Non-Alcoholic Fatty Liver Disease (NAFLD) progression, as it paves the way for severe liver injuries such as fibrosis and cirrhosis. The etiology of human NASH is multi-factorial and identifying reliable molecular players and/or biomarkers has proven difficult. Together with the inappropriate consideration of risk factors revealed by epidemiological studies (altered glucose homeostasis, obesity, ethnicity, sex…), the limited availability of representative NASH cohorts with associated liver biopsies, the gold standard for NASH diagnosis, probably explains the poor overlap between published "omics"-defined NASH signatures.

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