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Sperm derived H2AK119ub1 is required for embryonic development in Xenopus laevis

Archive ouverte | François-Campion, Valentin | CCSD

International audience. Ubiquitylation of H2A (H2AK119ub1) by the polycomb repressive complexe-1 plays a key role in the initiation of facultative heterochromatin formation in somatic cells. Here we evaluate the con...

Sperm derived H2AK119ub1 is required for embryonic development in Xenopus laevis

Archive ouverte | François-Campion, Valentin | CCSD

Deposition of H2AK119ub1 by the polycomb repressive complexe-1 plays a key role in the initiation of facultative heterochromatin formation in somatic cells. Here we evaluate the contribution of sperm derived H2AK119ub1 to embryo d...

Epigenetic homogeneity in histone methylation underlies sperm programming for embryonic transcription

Archive ouverte | Oikawa, Mami | CCSD

International audience. Sperm contributes genetic and epigenetic information to the embryo to efficiently support development. However, the mechanism underlying such developmental competence remains elusive. Here, w...

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